Index > Vol. 87/2007 > Iss. 3/May > pp. 219-222 > Abstract
Investigative Report | Skin tumors and pigmentation, Microbiology

Human Papilloma Virus in Skin, Mouth and Uterine Cervix in Female Renal Transplant Recipients With or Without a History of Cutaneous Squamous Cell Carcinoma

doi: 10.2340/00015555-0235

Abstract:

Some human papillomaviruses are thought to be associated with skin cancer. In this pilot study, 21 female renal transplant carriers, 10 with a history of skin squamous cell carcinoma and 11 without, together with 9 age-matched healthy women were investigated for human papillomavirus DNA in sun-exposed (forehead) and less sun-exposed (buttock) skin, mouth and uterine cervix. Paraffin-embedded tumours from 9 of the patients with a history of squamous cell carcinoma were analysed. Healthy skin from both the healthy and the immunosuppressed individuals harboured a wide variety of papillomaviruses. In the healthy individuals, samples from less sun-exposed skin showed a lower prevalence of human papillomavirus DNA than corresponding samples from the immunosuppressed patients (4/9 and 7/9, respectively). Among the immunosuppressed patients, human papillomavirus DNA was found as frequently in buttock samples (17/21) as in forehead samples (17/20). There was no increased prevalence of human papillomavirus in the cervix or mouth samples from the immunosuppressed patients.

Authors:

Peter Nordin, Bengt Göran Hansson, Carita Hansson, Ingemar Blohmè, Olle Larkö and Kristin Andersson

Key words:

human papillomavirus; kidney transplant patients; polymerase chain reaction; squamous cell carcinoma.

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